Ƶ

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
FILE PHOTO: A test tube labelled “Mpox virus positive” is held in this illustration taken August 20, 2024. (REUTERS)
Short Url
Updated 27 August 2024

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond

New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
  • Scientists say many questions remain about new clade Ib strain
  • Sexual transmission driving spread, but children infected, too

LONDON/CHICAGO: Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected and often in areas where experts lack the funding and equipment to properly track it.
That means there are multiple unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.
Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.
A new strain of the virus, known as clade Ib, has the world’s attention again after the WHO declared a new health emergency.
The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.
Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.
“I worry that in Africa, we are working blindly,” said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO’s mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.
“We don’t understand our outbreak very well, and if we don’t understand our outbreak very well we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease,” Ogoina said. “And I worry about the fact that the virus seems to be mutating and producing new strains.”
He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.
Mutating ‘more rapidly’
Mpox is an orthopoxvirus, the same family that causes smallpox. Population-wide protection from a global vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.
Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.
The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.
“All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it’s mutating a little bit more rapidly than we would expect,” he said.
Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.
In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia — likely due in part to deforestation and increased consumption of bushmeat, scientists said.
The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.
The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.
Children, pregnant women and people with weakened immune systems may be at greater risk of serious mpox disease and death, according to the WHO.
Clade I has typically caused more severe disease, with fatality rates of 4 percent-11 percent, compared to around 1 percent for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.
More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests.
Planning a response, including vaccination strategies, without this is difficult, the scientists said.
Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.
Getting samples to labs is difficult because the health care system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.
Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.
“This is not a luxury,” he said, but necessary to track deadly outbreaks.


At APEC, China’s Xi warns of growing ‘unilateralism’

At APEC, China’s Xi warns of growing ‘unilateralism’
Updated 54 min 41 sec ago

At APEC, China’s Xi warns of growing ‘unilateralism’

At APEC, China’s Xi warns of growing ‘unilateralism’
  • Xi is due to hold talks with his US counterpart Joe Biden on Saturday

LIMA: Chinese President Xi Jinping on Friday warned the world was entering an era of growing “unilateralism” and “protectionism,” in comments at a major Asia-Pacific trade summit in Peru.
Xi was in Lima for the Asia-Pacific Economic Cooperation (APEC) summit, and is due to hold talks with his US counterpart Joe Biden on Saturday.
“In a written speech addressing APEC CEO Summit 2024, Xi also warned of the spreading unilateralism and protectionism, and cautioned that the fragmentation of the world economy is increasing,” Chinese state news agency Xinhua reported.
In the wide-ranging speech, Xi said the world had “entered a new period of turbulence and transformation,” Xinhua reported.
In that context, he called for global industrial and supply chains to be kept “stable and smooth.”
US President-elect Donald Trump, set to take office in January, has promised a raft of protectionist trade policies, including 60 percent import tariffs targeting China, with whom he engaged in a trade war during his last term in office.
The Republican has once again signaled a confrontational approach to Beijing for his second term.
Xi said any attempts to reduce global economic interdependence was “nothing but backpedaling,” comments potentially aimed at Trump’s proposed policies on the campaign trail.
China, the world’s second-largest economy, has been reeling from headwinds on several fronts, with growth struggling to recover since the Covid-19 pandemic.
Beijing is pushing for an official national growth target this year of around five percent, a goal most economists believe it will narrowly miss.
But recent weeks have seen officials announce their most aggressive measures in years in a bid to breathe fresh life into the economy.
In Lima, Xi vowed to meet the GDP growth target, and to pursue economic liberalization policies that would “open its (China’s) door even wider to the world.”


Muslims who voted for Trump upset by his pro-Israel cabinet picks

Muslims who voted for Trump upset by his pro-Israel cabinet picks
Updated 15 November 2024

Muslims who voted for Trump upset by his pro-Israel cabinet picks

Muslims who voted for Trump upset by his pro-Israel cabinet picks
  • Muslim support for Trump helped him win Michigan and may have factored into other swing state wins, strategists believe
  • Hassan Abdel Salam, a former professor at the University of Minnesota said Trump’s staffing plans were not surprising, but had proven even more extreme that he had feared

WASHINGTON: US Muslim leaders who supported Republican Donald Trump to protest against the Biden administration’s support for Israel’s war on Gaza and attacks on Lebanon have been deeply disappointed by his Cabinet picks, they tell Reuters.
“Trump won because of us and we’re not happy with his Secretary of State pick and others,” said Rabiul Chowdhury, a Philadelphia investor who chaired the Abandon Harris campaign in Pennsylvania and co-founded Muslims for Trump.
Muslim support for Trump helped him win Michigan and may have factored into other swing state wins, strategists believe.
Trump picked Republican senator Marco Rubio, a staunch supporter of Israel for Secretary of State. Rubio said earlier this year he would not call for a ceasefire in Gaza, and that he believed Israel should destroy “every element” of Hamas. “These people are vicious animals,” he added.
Trump also nominated Mike Huckabee, a former Arkansas governor and staunch pro-Israel conservative who backs Israeli occupation of the West Bank and has called a two state solution in Palestine “unworkable,” as the next ambassador to Israel.
He has picked Republican Representative Elize Stefanik, who called the UN a “cesspool of antisemitism” for its condemnation of deaths in Gaza, to serve as US ambassador to the United Nations.
Rexhinaldo Nazarko, executive director of the American Muslim Engagement and Empowerment Network (AMEEN), said Muslim voters had hoped Trump would choose Cabinet officials who work toward peace, and there was no sign of that.
“We are very disappointed,” he said. “It seems like this administration has been packed entirely with neoconservatives and extremely pro-Israel, pro-war people, which is a failure on the on the side of President Trump, to the pro-peace and anti-war movement.”
Nazarko said the community would continue pressing to make its voices heard after rallying votes to help Trump win. “At least we’re on the map.”
Hassan Abdel Salam, a former professor at the University of Minnesota, Twin Cities and co-founder of the Abandon Harris campaign, which endorsed Green Party candidate Jill Stein, said Trump’s staffing plans were not surprising, but had proven even more extreme that he had feared.
“It’s like he’s going on Zionist overdrive,” he said. “We were always extremely skeptical...Obviously we’re still waiting to see where the administration will go, but it does look like our community has been played.”
The Trump campaign did not immediately respond to an email seeking comment.
Several Muslim and Arab supporters of Trump said they hoped Richard Grenell, Trump’s former acting director of national intelligence, would play a key role after he led months of outreach to Muslim and Arab American communities, and was even introduced as a potential next secretary of state at events.
Another key Trump ally, Massad Boulos, the Lebanese father-in-law of Trump’s daughter Tiffany, met repeatedly with Arab American and Muslim leaders.
Both promised Arab American and Muslim voters that Trump was a candidate for peace who would act swiftly to end the wars in the Middle East and beyond. Neither was immediately reachable.
Trump made several visits to cities with large Arab American and Muslim populations, include a stop in Dearborn, a majority Arab city, where he said he loved Muslims, and Pittsburgh, where he called Muslims for Trump “a beautiful movement. They want peace. They want stability.”
Rola Makki, the Lebanese American, Muslim vice chair for outreach of the Michigan Republican Party, shrugged off the criticism.
“I don’t think everyone’s going to be happy with every appointment Trump makes, but the outcome is what matters,” she said. “I do know that Trump wants peace, and what people need to realize is that there’s 50,000 dead Palestinians and 3,000 dead Lebanese, and that’s happened during the current administration.”


Trump promises to end wars with a ‘strong military’

Trump promises to end wars with a ‘strong military’
Updated 15 November 2024

Trump promises to end wars with a ‘strong military’

Trump promises to end wars with a ‘strong military’
  • “We’re going to work on the Middle East and we’re going to work very hard on Russia and Ukraine. It’s got to stop,” Trump added

PALM BEACH, United States: US President-elect Donald Trump on Thursday promised a “strong military,” as he repeated his pledge to end the war between Russia and Ukraine.
Trump, who campaigned on an “America First” foreign policy, has said previously that he wanted to strike a deal between Kyiv and Moscow, without giving details, and end bloodshed in the Middle East.
“We have to get back to a great country with low taxes and a strong military. We’re going to fix our military, we did once and now we’re going to have to do it again,” he said Thursday at a gala organized by the America First Policy Institute at his Mar-a-Lago resort in Palm Beach, Florida.
“We’re going to work on the Middle East and we’re going to work very hard on Russia and Ukraine. It’s got to stop,” Trump added.
He also criticized the “big chunk” of US spending on Afghanistan, from where American troops withdrew in 2021 after two decades of fighting an insurgency by the Taliban, which returned to power that year.
Trump’s re-election has the potential to upend the almost three-year conflict between Russia and Ukraine, throwing into question Washington’s multibillion-dollar support for Kyiv, which is crucial to its defense.
The Republican said on the campaign trail that he could end the fighting within hours and has indicated he would talk directly with Russian President Vladimir Putin.
Trump has not said how he intends to strike a peace deal on Ukraine or what terms he would propose.

 

 


Ukraine slams Scholz after first call with Putin in two years

Ukraine slams Scholz after first call with Putin in two years
Updated 15 November 2024

Ukraine slams Scholz after first call with Putin in two years

Ukraine slams Scholz after first call with Putin in two years
  • “This is exactly what Putin has been wanting for a long time: it is extremely important for him to weaken his isolation,” Zelensky said
  • Scholz spoke with Zelensky before and after the call with Putin, the chancellor’s spokesman said, but the early warning failed to quell Kyiv’s concerns.

BERLIN: Ukrainian President Volodymyr Zelensky Friday accused Germany’s Olaf Scholz of playing into the hands of Russian President Vladimir Putin after the chancellor spoke by phone to the Kremlin chief for the first time in almost two years.
In the call, Scholz “condemned Russia’s war of aggression against Ukraine and called on President Putin to end it and withdraw troops,” the chancellor’s spokesman Steffen Hebestreit said.
The German leader “urged Russia to show willingness to negotiate with Ukraine with the aim of achieving a just and lasting peace,” Hebestreit added in a statement.
The Kremlin confirmed the call between Scholz and Putin, which it said was held at the invitation of the German side.
Putin had a “detailed and frank exchange of views over the situation in Ukraine” with Scholz, the Kremlin said.
Putin told the German leader that any agreement to end the war in Ukraine “should take into account the security interests of the Russian Federation,” the Kremlin added.
An accord should “proceed from the new territorial realities and, most importantly, address the root causes of the conflict.”
Russia has demanded Ukraine surrender four regions as a precondition for talks, which Kyiv has rejected.
Ukraine responded angrily to Berlin reviving its lines of communication with Moscow. The call had opened a “Pandora’s Box,” Zelensky said.
“This is exactly what Putin has been wanting for a long time: it is extremely important for him to weaken his isolation,” Zelensky said.
Scholz spoke with Zelensky before and after the call with Putin, the chancellor’s spokesman said, but the early warning failed to quell Kyiv’s concerns.
“What is needed are concrete, strong actions that will force him to peace, not persuasion and attempts at appeasement, which he sees as a sign of weakness and uses to his advantage,” Ukraine’s foreign ministry said.
As well as Ukraine, Scholz also notified the countries of the so-called Quad, which includes France, the United States and Britain, a source close to French President Emmanuel Macron said.
The chancellor’s message to Putin was not “coordinated” between the allies but the French side expected to be informed on the contents, the source said.
During the hour-long call, Scholz “condemned in particular Russian air strikes against civilian infrastructure in Ukraine,” a German government source said.
Scholz “made it clear that sending North Korean soldiers to Russia for combat missions against Ukraine would lead to a serious escalation and expansion of the conflict,” the source said.
The German and Russian leaders “agreed to remain in contact,” while Berlin would keep its allies updated, the source added.
Scholz will have an opportunity for discussions at a meeting of G20 leaders in Brazil next week, from which Putin will be notably absent.
Putin has spoken to few NATO and Western leaders since 2022, when the EU and the US imposed massive sanctions on Russia for launching its shock Ukraine offensive.
His last known phone call with the leader of a major Western country was his previous conversation with Scholz in December 2022.
Almost 1,000 days after Russia launched its full-scale invasion, Ukraine is bracing for what could be the most difficult winter of the war so far.
Much of Ukraine’s energy infrastructure has been destroyed by Russian bombardments and Kyiv’s troops are increasingly on the back foot.
Germany has been one of Ukraine’s biggest military supporters, second only to the United States in the aid it has sent to Kyiv.
But the election of Donald Trump, who has criticized aid to Ukraine, as the next US president, has called into question Washington’s continued support.
Trump said on the campaign trail that he could end the fighting within hours and has indicated he would talk directly with Putin.
The Kremlin has denied reports that Putin and the president-elect of the United States recently discussed the Ukraine conflict by phone.
Scholz, who did speak with Trump following his election win, told the German daily Sueddeutsche Zeitung on Friday that the incoming US leader had a “more nuanced” position on the conflict than was commonly assumed.
Following the Putin-Scholz call, Polish Prime Minister Donald Tusk said he had been updated by the German leader on the discussion.
Tusk was “satisfied” that Scholz had “reiterated the Polish position: ‘Nothing about Ukraine without Ukraine’,” he said on social media platform X.


Croatian health minister arrested and sacked over alleged graft

Croatian health minister arrested and sacked over alleged graft
Updated 15 November 2024

Croatian health minister arrested and sacked over alleged graft

Croatian health minister arrested and sacked over alleged graft
  • Beros’ lawyer Laura Valkovic told local media that he denied any criminal responsibility
  • The prime minister’s comments came after Croatia’s Office for the Suppression of Corruption and Organized Crime (USKOK) said it was conducting several arrests

SARAJEVO: Croatian Health Minister Vili Beros was sacked on Friday after being arrested on suspicion of corruption, Prime Minister Andrej Plenkovic said.
Beros’ lawyer Laura Valkovic told local media that he denied any criminal responsibility. The health ministry declined to comment.
The prime minister’s comments came after Croatia’s Office for the Suppression of Corruption and Organized Crime (USKOK) said it was conducting several arrests.
The European Public Prosecutor’s Office also said it had initiated an investigation against eight people, including Beros and the directors of two hospitals in Zagreb, over alleged bribery, abuse of authority and money laundering.
Croatia’s State Attorney Ivan Turudic, whose office works closely with USKOK, said there were two parallel investigations into the alleged crimes and that EPPO has not informed his office nor USKOK about its investigation.
Turudic said Beros was accused of trade of influence. He said two other individuals had been arrested and one legal entity would be investigated on suspicion of the criminal act of receiving a bribe.
The people detained will be brought before an investigative judge who will decide on any pre-trial detention, Turudic told a news conference.
The EPPO said that a criminal group seeking to secure financing for the sale of medical robotic devices in several hospitals was suspected of giving bribes to officials to try to win contracts for projects, including EU funded ones.
“What is obvious is that this is about criminal acts of corruption,” Plenkovic said. “On behalf of the government, I want to say that agencies authorized for criminal persecution should investigate everything.”