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Gianluca Scamacca struck twice as visiting Atalanta upset Liverpool 3-0 in the first leg of the Europa League quarterfinals on Thursday.

The loss damages Liverpool’s hopes of a treble of trophies in manager Jurgen Klopp’s final season at Anfield.

The Italian visitors went into the break up 1-0 after Scamacca got a low drive past goalkeeper Caoimhin Kelleher in the 38th minute.

Klopp sent on Mohamed Salah, Dominik Szoboszlai and Andy Robertson as substitutes for the second half, but Scamacca netted again after Charles De Ketelaere fed him at the far post on the hour mark.

Mario Pasalic finished the scoring seven minutes from time.

Atalanta won at Anfield 2-0 in the group stage of the Champions League in 2020.

Liverpool won the English League Cup and are in a tight Premier League title race with Arsenal and Manchester City. Klopp’s team were eliminated from the FA Cup in the quarterfinals.

The lackluster display Thursday might turn out to be Klopp’s final European game at Anfield. The team needs a big comeback in Bergamo to stay alive.

If Liverpool reaches the Europa League final in Dublin on May 22, it would be Klopp’s final game in charge after nearly nine years.

Bayer Leverkusen got late goals from substitutes Jonas Hofmann and Victor Boniface to top West Ham 2-0 and extend their unbeaten streak to 42 games in a season that can also end up with a treble of trophies.

Hofmann netted on a rebound in the 83rd before Boniface clinched a well-deserved victory with a header in stoppage time.

With a 16-point lead atop the Bundesliga, Xabi Alonso’s team are on course to clinch their first-ever league title and have reached the German Cup final.

In an all-Italian matchup, Gianluca Mancini headed in a winner off a corner kick from Paulo Dybala to upset AC Milan 1-0 at San Siro.

Mancini also scored the lone goal in the Italian capital derby against Lazio on Saturday in Serie A.

It was the first win for Roma over Milan since October 2019.

Milan, the seven-time European champions, have never won the second-tier Europa League or its predecessor, the UEFA Cup.

Milan have never even reached the final — something Roma achieved twice, losing both in 1991 and last year.

Rafa Silva and veteran forward Angel Di Maria scored in each half for Benfica to beat Marseille 2-1. In an encounter of two former European champions. Pierre-Emerick Aubameyang pulled one back for Marseille, who lost their fifth straight game in all competitions.

Aubameyang has 24 goals this season in total.

The second-leg games will be played next week.

EUROPA CONFERENCE LEAGUE

Kostas Fortounis scored and provided an assist to help Olympiakos beat Fenerbahce 3-2 in the first leg of the Europa Conference League quarterfinals on Thursday.

Olympiakos built a 3-0 lead in Piraeus and held on after the Turkish team fought back with two second-half goals.

Fortounis opened the scoring after just eight minutes, netting his fifth goal of the European campaign. He then set up Stevan Jovetić to double the lead before halftime.

Chiquinho made it 3-0 with a precise low drive approaching the hour mark before Dusan Tadic pulled one back from the penalty spot and Ä°rfan Can Kahveci added the second for Fenerbahce.

Olympiakos is one of the two Greek teams in the last eight hoping to reach a home final in Athens.

The other, PAOK, lost 1-0 at Club Brugge.

Ollie Watkins and captain John McGinn scored early in each half to secure a 2-1 win for Aston Villa over Lille for manager Unai Emery, who claimed the Europa League on four occasions — three times with Sevilla and once with Villarreal.

Viktoria Plzen held last year’s runner-up Fiorentina to a 0-0 draw in what was the first European quarterfinal for the Czech club, which hasn’t conceded a goal for seven straight games in the third-tier competition.

As Fiorentina looked in control in the second half, the match was interrupted for several minutes because of flares that its fans threw onto the pitch.